A protein produced mainly by the liver, sex hormone binding globulin (SHBG) transports testosterone and estradiol in the blood, regulating their bioavailability. Doctors use SHBG levels to assess hormonal imbalances, particularly in diagnosing conditions like PCOS, hypogonadism, or thyroid disorders. Men with low SHBG and women with high SHBG often benefit from such evaluations.
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